John Mergenthaler is one of the smart drug gurus and co-author of books on smart drugs.
According to his publications, these are some of the best cited nootropic substances:
Acetyl-L-Carnitine: It is a natural amino acid that has great diversity of effects on various organs of the body. It has beneficial effects on depression and protects neurons. It also has an anti-aging effect. It improves cellular metabolism, memory, reaction time and other cognitive functions.
Dhea: It is a steroidal hormone that the adrenal gland produces. It is the steroid that has the highest concentration in the blood. It works to fight against obesity. It produces important cognitive improvements and has an anti-aging effect.
Ginkgo Biloba: It improves many brain functions, including memory, attention and concentration.
Phosphatidylserine: It nourishes the cell membranes of the brain and is at the same time a component of it. Supplementing with it will improve many cognitive functions that tend to decline with aging: memory, learning, concentration, mood and alertness. In addition, it maintains low levels of cortisol, the most destructive internal hormone, which is secreted in times of tension and feeling of danger.
Pregnenolone: Some authors consider it one of the most effective supplements. Its effects include: relieving stress, improving and prolonging energy levels, reducing joint inflammation, improving memory. It is also antidepressant.
Deprenyl: It is, according to some, the most promising therapy in the fight against aging. An antidepressant and sexual stimulant, it is also effective against Parkinson’s and Alzheimer’s.
Dihydroergotoxin: It is one of the most important smart drugs because it improves intellectual capacities in various ways and slows down the aging process.
Vinpocetine: Improves cerebral oxygenation and energy assimilation.
Centrophenoxin: It is an antiaging drug. It stimulates the chemical activity of the brain, in particular the assimilation of glucose.